ALK and non-small cell lung carcinoma: ALK rearrangement is one of the most common targeted mutations in NSCLC, ALK mutations in 3.9% of NSCLC were detected in this study, metastasis in 71% of ALK positive NSCLC patients, the metastasis rate was much higher than that in the wild-type group (71.0% vs. 47.4%, P < 0.001).