For example, the TDE of non-small cell lung cancer (NSCLC) has been shown to contain pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basal fibroblast growth factor (bFGF) while Time released these substances into the tumour microenvironment, these substances can stimulate endothelial cell activation and induce new blood vessel formation (82). This evidence concerns the gene FGF2 and non-small cell lung carcinoma.