HNF4A and neoplasm: In addition, H. H. Ma et al. designed and synthesized a ROS-based PS (Cy7-TCF-TK-IMC) by coupling Cy7-TCF to IMC via a thioketa (TK) linker, which then self-assembled into NPs and accumulate in tumors via the EPR effect, then actively targeting tumor cells via specific IMC/COX -2 pattern.