Y. Zhang et al. prepared a supramolecular assembled programmable immune activation nanomedicine (PIAN) as an in situ vaccine for cancer utilizing poly-[(N-2-hydroxyethyl)-aspartamide]-Pt (IV)/β-CD (PPCD), CpG/PAMAM-TK-adamantane (CpG/PAMAM-TK-Ad), and methoxy-PEG-thioketal-adamantane (mPEG-TK-Ad). The gene discussed is TKT; the disease is cancer.