ITPR2 and Hyperglycemia: As found in the atria, the overexpression of IP3R2 in the ventricular tissue of hyperglycemia-related cardiomyopathy disturbs the Ca2+ flux homeostasis between the ER and mitochondria, depresses mitochondria respiration and enhances oxidative stress and cardiomyocyte apoptosis (Wu et al., 2019; Zhang N. et al., 2023; Dubois et al., 2024).