BMP2 and osteoporosis: The systemic administration of TQ has been demonstrated to be effectivein accelerating the formation of new bone in the rapid maxillary expansion (RME)method [13] and healing of the defectscreated in the skull of osteoporosis rats [41].TQ induces bone repair by accelerating the differentiation of osteoblasts andactivating BMP-2 (bone morphogenetic factor-2) [43].