HIF1A and cancer: In vitro studies of MDA-MB-231breast cancer cells have shown hypoxia to stimulate prominent collagencross-linking through HIFs, knockdowns of which abolished collagencross-linking.45 These studies are consistentwith our previous findings where we showed that the radiation-resistantUM-SCC-47 tumors have higher content of HIF-1α.33 However, as with the lipid results, these studies needto be accompanied by investigations of the specific collagen-likespecies that appear to increase here.