Cell cycle arrest in the G2/M phase indicatesthat the cancer cell loses control of its cycle and drives it to deathby apoptosis.51 Followed by inducing astop in the cell cycle in HCT-116, PepGAT and PepKAA increase 2-foldthe number of apoptotic cells as revealed by the annexin assay (Figure 3), apoptosis mediatedby caspase 3/7 (Figure 4A) and the overaccumulation of ROS (Figure 4B). This evidence concerns the gene CASP3 and cancer.