SHMT2 and type 2 diabetes mellitus: Among them, 1,3,4-thiadiazole-based compounds were recentlyintroduced as potent α-GLY inhibitors.16−22 1,3,4-Thiadiazole compounds have also been reported to interactwith various targets, including α-AMY inhibitor,23 FFA1/PPARδ agonist,24 sodium-dependent glucose cotransporter-2 (SGLT-2) inhibitor,25 c-Jun N-terminal kinase inhibitor,23 and cannabinoid-1 receptor antagonist24 in the management of T2DM.