AKT1 and Insulin resistance: For example, others have reported elevated level of Akt phosphorylation in apparent cases of leg muscle insulin resistance(72–74) or in response to inflammation,(75) implying that the relationship between Akt phosphorylation and insulin-stimulated glucose transport may be context-specific, and that impairment in insulin-stimulated glucose transport by KIC may be mediated at steps distal to Akt.