An ideal model of Parkinson's disease should be age dependent and progressive.1 The PTEN-induced putative kinase 1 (P1) knockout (KO), in which the P1 gene is deleted, is a commercially available rat model for early-onset Parkinson's disease.2,3 Loss of function due to mutations in the P1 gene, important for preserving mitochondrial function in the brain, is linked to early-onset Parkinson's disease with slow progression.4,5 However, it is unclear whether this model may be beneficial for understanding the circuit mechanisms involved in Parkinsonian gait dysfunction. This evidence concerns the gene PINK1 and Parkinson disease.