Additionally, two variants (MT:750G>A and MT:153A>G) were found to positively correlate with obesity risk, and one variant (MT:1243T>C) was exclusively found in the obese group within the MT-RNR1 gene, which encodes the MOTS-C protein known for promoting metabolic homeostasis and obesity reduction (42). This evidence concerns the gene NR4A2 and obesity due to melanocortin 4 receptor deficiency.