CD8A and non-Hodgkin lymphoma: It has been proposed that LD-RT may increase the number of leukocytes in the circulation and thus improving treatment outcome.30 One study of Non-Hodgkin’s Lymphoma demonstrated a transient increase in CD4+ T cells and an increase in CD4+/CD8 + ratio.13 We did not observe increase numbers of any of the leukocyte populations measured.