CD4 and inflammatory bowel disease: While we did not observe a relative difference in colonic TNFRSF14 expression in either UC or CD patients compared to non-IBD controls, others have found that the absence of Tnfrsf14 accelerated intestinal inflammation in an induced colitis model by transfer of CD4+CD45RBhigh T cells to Hvem−/−Rag−/− mice27,28.