CRP and rheumatoid arthritis: Significant improvements were also observed in DAS28-3 (CRP), ACR50, ACR70, and Health Assessment Questionnaire–Disability Index (HAQ-DI).33 In a study involving 66 RA patients on csDMARDs, Gharib et al. observed that adding Metformin significantly lowered serum CRP and adiponectin levels, reduced disease activity, and improved patients’ quality of life (Table 3).