Conversely, cancer cells become more drug sensitive when NFE2L2/Nrf2 is overexpressed because it causes chemoresistance in HCC (Cai et al., 2020), whereas medication sensitivity is caused by downregulation of USP7, which also inhibits HCC cell proliferation and metastasis (Zhang et al., 2020). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.