Furthermore, BECN1 controls autophagic activity via interacting with other ATG proteins, the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, and TP53/p53 (tumor protein p53), among other autophagy mediators, which in turn affects the initiation and progression of cancer (Yun et al., 2020). This evidence concerns the gene TP53 and cancer.