Obesity, PIK3CG/PI3Kγ (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) ablation, ZRANB1 (zinc finger RANBP2-type containing 1), and ADORA2A-AS1 (ADORA2A antisense RNA 1) all contribute to HCC development. This evidence concerns the gene PIK3CG and obesity due to melanocortin 4 receptor deficiency.