AE, adverse event; APS, abdominal pain score; CD, Crohn’s disease; CDAI, Crohn’s Disease Activity Index; HBI, Harvey-Bradshaw Index; IBDQ, Inflammatory Bowel Disease Questionnaire; JAK, Janus kinase; SAE, serious adverse event; SF, stool frequency; TNF, tumor necrosis factor; UC, ulcerative colitis. The gene discussed is TNF; the disease is Crohn disease.