It is a systemic infection caused by the human-adapted pathogen Salmonella enterica serovar Typhi or Salmonella typhi [4]. Here, we present an interesting case with co-infection of dengue virus (DV) (confirmed by serum IgM enzyme-linked immunosorbent assay (ELISA)) and typhoid encephalopathy (confirmed by blood cultures, serum IgM ELISA, and cerebrospinal fluid (CSF) reverse transcription-polymerase chain reaction (RT-PCR) for Salmonella typhi), manifesting choreoathetoid movements in the fever ward. This evidence concerns the gene CD40LG and coinfection.