AGT and hypertensive disorder: TMAO can also extend the effects of angiotensin II-induced vasoconstriction, promoting angiotensin II-induced hypertension and causing the glomerular filtration rate (GFR) to decrease through the protein kinase R-like ER kinase (PERK)/reactive oxygen species (ROS)/calcium/calmodulin-dependent protein kinase II (CaMKII)/PLC3 pathway.