SMAD3 and connective tissue disorder: It is important to check for connective tissue disorders, a possible risk factor for CAD, especially vascular Ehlers-Danlos syndrome (COL3A1 gene) and, to a lesser extent, Marfan syndrome (fibrillin 1 gene), osteogenesis imperfecta (COL1A1 or COL1A2 gene), and Loeys-Dietz syndrome (TGFBR1, TGFBR2, TFFB2, or SMAD3 gene) [1].