The driver mutations typically observed in most NSCLC, such as tumor protein p53 (TP53), Kirsten rat sarcoma viral oncogene homolog (KRAS), epidermal growth factor receptor (EGFR), or anaplastic lymphoma kinase (ALK), and ROS proto-oncogene 1 (ROS1) translocations, are rarely present. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.