Dexmedetomidine, an alpha-2 agonist used for sedation, has shown promise in reducing postoperative delirium, especially when added to general anesthesia regimens. Zhang et al. found that administering dexmedetomidine at 0.5 mcg/kg/hr 30 minutes before the start of anesthesia, continuing the infusion at 0.3 mcg/kg/hr throughout surgery, and discontinuing it 30 minutes before the end of surgery may decrease the incidence of postoperative delirium in elderly patients [48]. Here, PSMA2 is linked to delirium.