The most frequently observed cytogenetic/molecular abnormality in non-Down syndrome neonatal leukaemia is t(4;11)(q21.3;q23.3)/KMT2A-AFF1 followed by t(1;22)(p13.3;q13.1)/RBM15-MKL1 and t(8;16)(p11.2;p13.3)/KAT6A-CREBBP [2]. The gene discussed is AFF1; the disease is Down syndrome.