ESR1 and neoplasm: No significant association between HER2/neu status and tumor was observed. Additionally, these markers showed significant association with each other with p-values (ER/PR <0.0001 and Cramér's V of 0.8 describing a very large association, ER/HER2 of 0.02 and Cramér's V of 0.3 indicates moderate association, PR/HER2 of 0.002 and Cramér's V of 0.4, which also shows moderate association).