ESR1 and cancer: In the context of BC, it was concluded that Axl's high expression correlated with poor differentiation, indicating its role in developing BC; additionally, it was revealed that Axl causes the upregulation of ER and PR, but the exact mechanism is not clear and requires further investigation [9]. It was concluded in several studies that the Axl receptor was primarily responsible for forming metastasis in epithelial-like cancers (ER+, HER2+).