We then looked at the transcript levels of these genes and found that, consistent with the protein levels, the transcription of Notch1, Sox2, and the stem cell marker Aldh1a3 genes were suppressed, while that of Numb was elevated, in response to RAB4A knockdown in RAB4A-high cancer cells (Fig. 2D–F). The gene discussed is ALDH1A3; the disease is cancer.