The p53 groups developed tumors significantly faster (25 days vs. 33 days, p = 0.0001) and more reliably (HR 2.9, 95% CI 1.7-5.0; p = 0.0002) than the BPB groups (Fig. 2A-C), with the fastest median times to tumor take occurring in the p53 male Pgk1-Cre/SB13 + Kras + Cmyc group (20 days), p53 male Cdh1-Cre/SB13 + Kras + Cmyc group (22,5 days) and p53 male KRT14-Cre/SB13 + Kras + Cmyc group (23 days) (Supp. The gene discussed is TP53; the disease is neoplasm.