DCX, a microtubule-associated protein crucial for neuron migration and neocortical and hippocampal development, has been associated with significant developmental disorders in humans (lissencephaly) and mice (hippocampal lamination abnormalities), affecting learning and social behaviours (Corbo et al. 2002; Kappeler et al. 2007; Vukovic et al. 2013; Germain et al. 2013). This evidence concerns the gene DCX and lissencephaly spectrum disorders.