This pathway promotes neuronal sensitization through CCR4-expressingcells and affects obesity-related pain symptoms [70].In OA pain, GM-CSF triggers inflammation via the GM-CSF/Jmjd3/IRF4/CCL17 pathway, and theinhibition of CCL17 ameliorates GM-CSF-induced inflammatory pain, arthritic pain, anddiseases [71]. Here, CSF2 is linked to obesity due to melanocortin 4 receptor deficiency.