showed that gene activation as a result of histone crotonylation plays a key role in acute kidney injury (AKI).[39] An increase in kidney tissue histone Kcr was observed during AKI, specifically at the genes encoding peroxisome‐proliferator‐activated receptor gamma coactivator‐1α (PGC‐1α), a mitochondrial biogenesis regulator, and sirtuin‐3 (SIRT3), a decrotonylase. The gene discussed is SIRT3; the disease is acute kidney injury.