Furthermore, human menstrual blood‐derived stem cells effectively upregulate the expression of BNIP3 and BNIP3L by mediating significant DNA promoter demethylation through ten‐eleven translocation methylcytosine dioxygenase 2 (TET2), thereby reversing sorafenib resistance in HCC cells.202. The gene discussed is TET2; the disease is hepatocellular carcinoma.