LDLR and atherosclerosis: Furthermore, all female mice developed more severe atherosclerosis under diabetic conditions compared to their male counterparts, showing an increase of plaque burden in the aortic tree both among the control groups (Ldlr−/−, female vs. male, 9.63%±0.864% vs. 8.18%±1.128%) and transgenic groups (KLF11ECtg-Ldlr−/−, female vs. male, 4.99%±0.578% vs. 2.72%±0.578%) (Fig. 3B-C).