Top over-represented EV proteins from the adenoma ZMTH3 (Table 4) were mainly related to immune response (ISG15, BST2, IFI44), while top under-represented proteins identified in the adenoma ZMTH3 EVs were associated with migratory and adhesion activity (MXRA8, TNN, SERPINB8) (Table 4), similar to the WCLs. The gene discussed is MXRA8; the disease is adenoma.