Furthermore, top over-represented proteins in carcinoma EVs (Additional file 6) included ECM-related proteins associated with migration and adhesion (LUM, COL14A1, FN1) whereas top under-represented proteins from carcinoma EVs included proteins associated with RNA processing (ELAVL2, SNU13, SARS2) (for associations and references of proteins listed in Table 4 and Additional file 5 with cancer studies, refer to Additional file 7). This evidence concerns the gene COL14A1 and cancer.