Moreover, carcinoma EVs shared 85 under-represented proteins involved in regulating the cellular protein metabolism (ASPSCR1, DIS3L2, C1QBP) (Table 6), whereas complex carcinoma EVs shared 506 under-represented proteins, with the least abundant being involved in RNA processing and cell cycle (WDR3, TP53, BRIX1, RPS13) (Additional file 8). This evidence concerns the gene BRIX1 and carcinoma.