Additionally, 361 proteins were commonly under-represented in both adenoma and carcinoma cell lines (Fig. 2f), which were mainly associated with DNA replication, transcriptional activation and cell cycle regulation (NOC3L, TRIT1, CDK2, USP19) (Table 2); whereas the carcinoma cell lines shared 435 under-represented proteins, including splicing and chromatin regulator proteins (RTCB, SMARCA4) (Table 3, Additional file 2). The gene discussed is RTCB; the disease is adenoma.