TPM4 and carcinoma: Among the most over-represented proteins in the WCLs of carcinoma cell lines, proteins associated with actin cytoskeleton-rearrangement (TPM4, MYLK, PTK2B) as well as cell adhesion and migration (MDK, EPCAM) were detected (Additional file 2), thus indicating increased migratory and adhesion activity in the carcinoma cell lines.