IFNG and neoplasm: After coculture with CCRF-CEM cells overnight, 5D CAR-NK cells and 12 C CAR-NK cells exerted robust and specific tumor-killing activity relative to control NK cells, and stronger cytotoxicity and more IFN-γ release were observed in 12 C CAR-NK cells compared to those in 5D CAR-NK cells (Fig. 3d).