In the co-transfected group, migration was between the CHRDL1 overexpression group and the MED29 group, suggesting that MED29 can reverse the inhibitory effect of CHRDL1 on oral cancer migration, indicating that CHRDL1 plays a regulatory role in the CHRDL1-MED29 signaling axis. The gene discussed is CHRDL1; the disease is lip and oral cavity carcinoma.