MANF and myocardial infarction: Similarly, Dong, Jia and colleagues detected an augmented release of MANF following ER stress induced by ischemia: elevated MANF levels were observed in HL-1 cells following hypoxia/reoxygenation (H/R) stimulation, and increased MANF levels were also found in the serum of MI patients and I/R mice (Dong et al. 2024).