NFKB1 and asthma: Experiments with mice have shown a reduction in EpOMEs and dihydroxy octadecenoic acids (DiHOMEs) when fed a high-fat diet supplemented with the omega-3 α-linolenic acid (ALA).131 This also led to a lowering in the omega-6:omega-3 ratio, a decline in NFκB activation, divergence of M1 macrophages, and insulin resistance.131 12,13-DiHOME increased Th2 cells, which increased the risk of developing asthma.132 In children suffering from asthma, the cell numbers of Candida and Rhodotorula spp.