CSNK2B and Poirier-Bienvenu neurodevelopmental syndrome: CSNK2B, on the other hand, has recently been shown to be associated with autosomal dominant Poirier-Bienvenu neurodevelopmental syndrome (POBINDS; MIM#618732), in which truncating variants in CSNK2B result in haploinsufficiency, leading to early-onset seizures and highly variable impairments of intellectual functioning26–28.