New bulk RNA sequencing (RNA-seq) data revealed differences in mucosal innate immune response gene expression in mice with germline disruption of Ptk6. In publicly available datasets [27, 28], we detected increased Ptk6 expression in the intestine following infections with the nematode parasite Heligmosomoides bakeri (Hb) or Salmonella, different activators of type 2 immunity. The gene discussed is GSTM1; the disease is infection.