,183 The function of this leak flux seems to be rinsing the intestinal epithelium to wash away pathogens or inflammation-inducing factors, similar to the mechanism of “enteric tears.”184 However, claudin-2 upregulation promotes progression of immune-mediated experimental colitis underlining that claudin-2 has complex functions in mucosal (patho)physiology.185. The gene discussed is CLDN2; the disease is colitis.