Further analysis of the differential expression of IL-1 family and related genes in normal tissues and HPV- and HPV+ tumor tissues (Table 2) revealed that IL-1α, IL-1β, IL1R1, IL1R2, IL1RL1, IL1RAP, IL1F10, IL-18 and CASP1 were highly expressed in HPV- tumors. Here, IL1R1 is linked to neoplasm.