In this study, it was found that IL-1α, IL-1β, IL1R1, IL1RL1, IL1F10, IL33, CASP1, and AIM2 were highly expressed in head and neck tumors, while IL1RN, IL1RAPL1, IL1RAPL2, IL18BP, IL18R1, and IL18RAP were low in expressed, which is consistent with previous literature. Here, IL1RAPL2 is linked to head and neck neoplasm.