In this study, it was found that IL-1α, IL-1β, IL1R1, IL1RL1, IL1F10, IL33, CASP1, and AIM2 were highly expressed in head and neck tumors, while IL1RN, IL1RAPL1, IL1RAPL2, IL18BP, IL18R1, and IL18RAP were low in expressed, which is consistent with previous literature. The gene discussed is IL18R1; the disease is head and neck neoplasm.