In this study, it was found that IL-1α, IL-1β, IL1R1, IL1RL1, IL1F10, IL33, CASP1, and AIM2 were highly expressed in head and neck tumors, while IL1RN, IL1RAPL1, IL1RAPL2, IL18BP, IL18R1, and IL18RAP were low in expressed, which is consistent with previous literature. This evidence concerns the gene IL1RN and head and neck neoplasm.