TRIM27 is involved in lupus nephritis (LN) and IgA nephropathy (IgAN), via two distinct pathways. DKD pathology differs from the immune‐related pathology of LN and IgAN, yet this work highlights that cellular pathways may overlap. Targeting TRIM27 to mediate its expression may be useful to reduce injury of glomerular endothelial cells in LN, with the scope to explore this in DKD. This evidence concerns the gene TRIM27 and diabetic kidney disease.