Gene expression was significantly reduced in DKD in all but one of the seven kidney datasets in Nephroseq.76 Higher FKBP5 mRNA is associated with a pro‐inflammatory profile.88 Encodes FKBP51, regulator of Akt phosphorylation,89 nuclear factor‐kappa B (NF‐κB) activation90 and glucocorticoid receptor signalling.91 Hypomethylation at cg03546163 has previously been associated with DKD (p = 2.4 × 10−9)77 and kidney failure75 in T1D. Differential methylation of FKBP5 is associated with multiple other diseases, including T2D and cardiometabolic risk92. This evidence concerns the gene FKBP5 and type 2 diabetes mellitus.