YAP1 and neoplasm: The Hippo signaling pathway is a tumor suppressor pathway initially identified in Drosophila, playing a key role in regulating tissue homeostasis, organ development, and tumor suppression.16 The regulatory role of the Hippo signaling pathway in tumors has been reported in various tumors, such as BC,17 liver cancer,18 lung cancer,19 pancreatic cancer,20 and colorectal cancer.21 Several studies have confirmed that the Hippo/YAP1 axis plays a vital role in TNBC.