TBX1 and 22q11.2 deletion syndrome: Loss of Tbx1 in mice results in a shortened distal OFT with development of the anterior ICVS impacted,19,65 and we have identified comparable phenotypes in the zebrafish tbx1 mutant (Figure 6), mirroring the congenital heart malformations seen in 22q11.2 deletion syndrome (DiGeorge).