As with the young mice, VSV-Spike-mIFNß boosted the anti-VSV-N T-cell response following an initial prime with VSV-Spike-mIFNß, but previous treatment with SC-Ad-Spike significantly reduced the anti-VSV T-cell response, presumably due to the neutralization of the boost dose of VSV-Spike-mIFNß by SC-Ad-Spike-induced anti-Spike Ab, which prevented infection by the incoming VSV (Figure 4C). The gene discussed is CHMP5; the disease is infection.