Notably, many of the enriched core genes in the BTMs with most weakened regulation in HD subjects were differentially targeted by MECP2 and MBD2, including TGFBR3, IL2RB, TNF, and all of the core enriched genes in LI.M94.0 (growth-factor-induced, enriched in nuclear receptor subfamily 4). This evidence concerns the gene MBD2 and Huntington disease.