Interestingly, LI.M146 (MHC-TLR7-TLR8) was another BTM found to exhibit weakened targeting in HD subjects, and features the core enrichment genes TLR7 and TLR8, which have been shown to induce type 1 IFNs in DCs that synergize with the NFkB pathway to activate DCs [45]. The gene discussed is TLR8; the disease is Huntington disease.