SMAD2 and Huntington disease: Except for MAP3K8, which was more strongly regulated in HD patients, all of the remaining core enrichment genes exhibit decreased regulation by several transcriptional repressors, including the decreased targeting of ICAM by MBD2, DNMT1, and E2Fs, as well as the decreased targeting of TNF by ZBTB4, MECP2, TGIF1, ZNF350, and SMAD2.