The NAT (+)/HBsAg (−)/Anti-HBc (−) occult hepatitis B profile was found in only one donor (0.03%), in contrast to the study by Pondé (2013) that considered this profile a relatively common finding in blood banks when contact with HBV was very recent and other serological markers of the infection had not yet emerged, or even by the occurrence of the X-mutant virus, generally characterized by a deletion of eight nucleotides between positions 1770 and 1777 and a point mutation from a thymine to a cytosine in the X-ORF region [32]. This evidence concerns the gene BRD2 and infection.