Mechanistic insights confirmed the downregulation of several genes associated with the epithelial–mesenchymal transition (EMT) and cancer stemness (e.g., SNAIL1, TWIST1, ZEB1, and ZEB2, E-cadherin (CDH1), Vimentin, CD133, Thy1, CDH2, fibronectin, and alpha-SMA) upon HBx knockdown [52]. The gene discussed is CDH1; the disease is cancer.