To determine if a phenomenon similar to receptor downregulation could be observed for ADAM17 upon pestivirus infection, MDBK cells were infected with different pestivirus species, cytopathic BVDV-1 (cpBVDV-1), BVDV-2, CSFV, strain giraffe (Pestivirus giraffae) or LindaV, or mock treated. This evidence concerns the gene ADAM17 and pestivirus infectious disease.