A bioinformatics analysis of the single-cell and bulk RNA-seq profiling of COVID-19 patients’ data revealed a significant upregulation of cGAS-STING signalling pathway genes (TMEM173, IRF3, NFKB1, CGAS, IFNAR1, and TBK1) in the lung (Figure S1). The gene discussed is IRF3; the disease is COVID-19.