Experiments in NPC cell lines have been used to demonstrate that LMP1 has some anti-apoptotic functions in which it can upregulate the NF-κB pathway, thereby enhancing MDM2, an E3 ubiquitin ligase, binding to p53, and leading to increased p53 proteasomal degradation [37,38,39]. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.