Because of the pro-inflammatory role of IL17 and TLR4, the objectives of the current study were to explore the associations between (i) IL17 (A7448G and G197A) and TLR4 (Asp299Gly and Thr399Ile) gene polymorphisms and MASLD susceptibility; (ii) IL17 (A7448G and G197A) and TLR4 (Asp299Gly and Thr399Ile) gene polymorphisms and MASH/MAFL susceptibility at the allelic, genotypic, and haplotypic level; and (iii) to test the effect of the studied gene polymorphisms on plasmatic levels of IL17 and TLR4 in MASLD patients as well as in controls. This evidence concerns the gene IL17A and metabolic dysfunction-associated steatotic liver disease.